A142 west of Ely closed for the day after fatal accident
Police are asking drivers to avoid the area.
Emergency services were called at around 6am to reports of a serious collision involving four cars and a lorry on the A142 at Mepal.
One person has died and several people have been injured.
Officers are at the scene and police are asking people to advise motorists to avoid the area as the road is likely to be closed for the rest of the day.