Home   News   Article

Wellcome Sanger Institute research uncovers how parasitic whipworms are able to thrive in our guts


By Paul Brackley


The human whipworm infects an estimated 500 million people globally, causing the neglected tropical disease trichuriasis.

The whipworm Trichuris trichiura is parasitic helminthic nematode (roundworm) under the microscope view (7226625)
The whipworm Trichuris trichiura is parasitic helminthic nematode (roundworm) under the microscope view (7226625)

The worm - Trichuris trichiura - has evolved over millennia to infect the intestines and reproduce there.

Wellcome Sanger Institute researchers and their collaborators have now identified the master regulator, known as the interleukin 10 receptor (IL-10R), that maintains a healthy gut and limits damage by parasitic whipworms.

In mice, a lack of IL-10R regulation led to an uncontrolled immune response that damaged the gut lining and led to a failure to produce protective mucus.

The worms invading the gut-lining cells destroyed the barrier between the gut and host, enabling bacteria to cross over into the rest of the body, causing fatal infection.

Dr Maria Duque-Correa, first author from the Wellcome Sanger Institute, said: “This work shows how any change in the host or microbiota will also change the response to whipworms. Interactions between the host cells, microbiota and whipworms enable the whipworms to survive in infected individuals and now we’ve found a master regulator of those interactions.”

Unravelling this signalling mechanism will help scientists understand immune response to other parasites and sheds light on pathways that could be involved in the control of other diseases, such as inflammatory bowel disease and allergies.

The egg of the parasitic whipworm, Trichuris trichiura, a helminthic nematode (roundworm) under the microscope (7226627)
The egg of the parasitic whipworm, Trichuris trichiura, a helminthic nematode (roundworm) under the microscope (7226627)

Prof Richard Grencis, an author from the University of Manchester, said: “This is the first study revealing the master role of IL-10R in regulating the response to whipworm, and controlling the microbiota. We discovered the absence of this crucial signalling pathway leads to disturbed microbiota and uncontrolled inflammation that destroys the gut lining allowing microbes to invade and cause liver failure.”

Dr Matt Berriman, senior author from the Wellcome Sanger Institute, said: “Our discovery of the importance of the IL-10R signalling pathway for gut regulation not only helps us understand the immune response to parasites, it also has implications for other diseases.

“Further research to better understand this immune signalling pathway could open up new ways of finding treatments for diseases caused by an overactive immune system such as allergies, inflammatory bowel disease or asthma.”

The study was published in PLOS Pathogens.

Read more

Scientists aim to sequence all 1.5 million known species on Earth - and Wellcome Sanger Institute will play leading role

Wellcome Sanger Institute researchers uncover new clues about childhood diseases

25 species genomes have been sequenced to mark Wellcome Sanger Institute's 25th anniversary



COMMENTS
()


Iliffe Media does not moderate comments. Please click here for our house rules.

People who post abusive comments about other users or those featured in articles will be banned.

Thank you. Your comment has been received and will appear on the site shortly.

 

Terms of Comments

We do not actively moderate, monitor or edit contributions to the reader comments but we may intervene and take such action as we think necessary, please click here for our house rules.

If you have any concerns over the contents on our site, please either register those concerns using the report abuse button, contact us here.

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies - Learn More